Incretin Hormones Study
Are you eligible?
Inclusion Criteria:
- Confirmed diagnosis of CF
- Individuals age ≥ 18y
- Pancreatic insufficiency
- Recent OGTT consistent with Indeterminate-GT, IGT, CFRD w/o fasting hyperglycemia,
or an established diagnosis of CFRD without fasting hyperglycemia
- For female subjects, negative urine pregnancy test at enrollment.
Exclusion Criteria:
- Established diagnosis of non-CF diabetes (i.e. T1D)
- History of pancreatitis within last year
- Prior lung or liver transplant
- Severe CF liver disease, as defined by portal hypertension
- Fundoplication-related dumping syndrome
- Medical co-morbidities that are not CF-related or are unstable
- Acute illness or changes in therapy (including antibiotics) within 4 weeks prior to study procedures
- Treatment with oral or intravenous corticosteroids within 4 weeks of study
- Hemoglobin <10g/dL
- Abnormal renal function
- Personal or family history of medullary thyroid cancer or history of Multiple
Endocrine Neoplasia 2