Incretin Hormones Study

Are you eligible?

Inclusion Criteria:

  • Confirmed diagnosis of CF
  • Individuals age ≥ 18y
  • Pancreatic insufficiency
  • Recent OGTT consistent with Indeterminate-GT, IGT, CFRD w/o fasting hyperglycemia, or an established diagnosis of CFRD without fasting hyperglycemia
  • For female subjects, negative urine pregnancy test at enrollment.

Exclusion Criteria:

  • Established diagnosis of non-CF diabetes (i.e. T1D)
  • History of pancreatitis within last year
  • Prior lung or liver transplant
  • Severe CF liver disease, as defined by portal hypertension
  • Fundoplication-related dumping syndrome
  • Medical co-morbidities that are not CF-related or are unstable
  • Acute illness or changes in therapy (including antibiotics) within 4 weeks prior to study procedures
  • Treatment with oral or intravenous corticosteroids within 4 weeks of study
  • Hemoglobin <10g/dL
  • Abnormal renal function
  • Personal or family history of medullary thyroid cancer or history of Multiple Endocrine Neoplasia 2