Incretin Hormones Study
About this Study
The insulin deficiency related to CFRD has traditionally been considered a by-product of damage to the
exocrine pancreas (the part of the pancreas responsible for making digestive enzymes) that extends to
the endocrine pancreas (which makes insulin and other hormones). In type 2 diabetes, abnormalities in
gut secreted hormones (referred to as incretins) that help the pancreas secrete more insulin after eating
have been recognized.
Through this study, we hope to obtain more information regarding Beta cell responsiveness to incretin
hormones in individuals with CF, and to determine whether the gut’s ability to make these hormones or
the pancreas’ ability to respond to these hormones is altered in CF.
With this information, we hope to better understand how individuals with CF secrete insulin. This will
equip both providers and individuals with CF with the knowledge to better understand and manage this condition,
and lessen its assault on pulmonary health.