Genetics Study

Are you Eligible?

Genetics Phase, Visit 1


Inclusion:

  • Individuals age > 2 years
  • Confirmed diagnosis of Cystic fibrosis
  • For subjects< 18 years, parental/guardian permission (informed consent) and if appropriate, child assent

Exclusion:

  • Established diagnosis of non-CF diabetes (i.e. Type1 diabetes)

Phenotyping Phase, Optional visits 2 and 3


Inclusion:

  • Individuals age >8 years
  • Confirmed diagnosis of Cystic Fibrosis
  • For subjects< 18 years, parental/guardian permission (informedconsent) and if appropriate, child assent
  • Pancreatic insufficient
  • High diabetes risk or low diabetes risk TCF7L2 genotype

Exclusion:

  • Established diagnosis of non-CF diabetes (i.e. T1D) or CFRD
  • History of clinically symptomatic pancreatitis within last year
  • Prior lung or liver transplant
  • Severe CF liver disease, as defined by presence of portal hypertension
  • Fundoplication-related dumping syndrome
  • Medical co-morbidities that are not CF-related or are unstable
  • Acute illness or changes in therapy (including antibiotics) within 4 weeks prior to study procedures
  • Treatment with oral or intravenous corticosteroids within 4 weeks of study
  • Hemoglobin <10 g/dL
  • Abnormal renal function