About CFRD

Cystic Fibrosis related diabetes (CFRD) is a serious co-morbidity that commonly affects adolescents and adults with CF and can result in worse lung function, worse nutritional status, and decreased survival. The diabetes that occurs in CF is largely caused by the body’s inability to make sufficient amounts of insulin. Insulin is a hormone made in the pancreas by specific endocrine cells called beta cells. Insulin works to help the cells in your body receive all of the energy from the carbohydrates, protein, and fat in the food you consume.


Typically, this process works in the following way:

  • Your digestive system converts the carbohydrates that you eat into a simple sugar, known as glucose
  • Glucose enters your bloodstream and signals the beta cells in the pancreas to release insulin
  • Insulin then helps the cells in your body take up the glucose from the blood to use immediately as fuel or to store for later use
  • Insulin also signals the body to store fat and protein